The round 13 blockbuster sees the Gators sitting in second and the Cougars in third.
Last time out Keysborough picked up a four-point overtime win. Shepparton coach Josh Waight said his side was looking forward to another great hit-out.
“These guys (Keysborough) have been the benchmark in the competition for the last couple of years so we’re really excited to take on the best,” Waight said.
“The support from the locals has been fantastic this year and hopefully they can get out again on Saturday night and cheer us to get over the line.”
Waight said Matt Bartlett would likely remain out of the squad through injury, while Tom Frame will miss due to illness.
“We’re missing a couple but with that being said it gives other players the opportunity to step up and play some bigger minutes,” Waight said.
“Their (Keysborough) import is having a pretty good season, Gerrard Newby, I think they’re close to full strength now so they’re a pretty well-rounded team and have a lot of offensive firepower so we really need to make sure we do a good job on the defensive end.
“We have a triple-header this weekend, anyone local that’s interested in basketball, get down to the Swamp, there are a couple of youth league games before us which we haven’t had this year so that will be exciting as well.”
The round 13 clash is a must-win if the Gators side wants to end the season in the top two.
Saturday night’s game will tip off at 8pm at the Shepparton Sports Stadium with two youth league two games scheduled beforehand.
The curtain-raisers will begin at 4pm with the Wangaratta North East Bushrangers men’s side taking on Wallan, followed by the Bushrangers women battling Wallan at 6pm.