On Monday, frustrated farmers and business owners impacted by the plan will travel on a "Convoy to Canberra".
It is believed a large number of farmers from the Goulburn Valley and Southern Riverina are set to leave their farms for the day.
Kaarimba hay and grain farmer Col Grinter is one of the farmers making the trip.
He said he wouldn't be surprised if farming in this region is soon wiped out.
"The MDBP is destroying this area," he said.
"It's so bad our clients who usually rely on us have literally disappeared off the face of the earth and it's all because they don't have water."
Mr Grinter said he's "sick and tired" of hearing Federal Water Minister David Littleproud blame the drought for farmers' problems rather than focusing on the plan.
Victorian Member for Shepparton Suzanna Sheed said she'll also be heading to the nation's capital.
Ms Sheed has made numerous calls in the past for the plan to be scrapped.
"It is sign of how desperate these hard-working people are that they feel the need to take their grievances directly to Canberra," Ms Sheed said.
"If you know anything about dairy farmers, you know taking two days out of their busy working week is no small undertaking. The least I can do is go as well and try to help lend my voice to theirs."
City for Greater Shepparton's most vocal councillor on water policy, Dennis Patterson, said he won't be attending but did throw his support behind the cause.
Cr Patterson said the impact on farmers has been devastating.
"I've heard the tag line 'This plan is better than no plan' but that's nonsense, this plan must go.
"When you have water running past your property because it has to travel 800km away and you can't touch it, baffles me."
Cr Patterson said during his recent travels to QLD some of the towns in the northern Darling are also severely impacted by the MDBP.
Member for Farrer and Environment Minister Sussan Ley said not all water policy is dictated by the federal government.
"People have the right to protest, of course, but it is important to note it is the states which control who gets how much of their annual entitlement of water, not the Commonwealth.
"Right now, water for the environment in the Murray system is also on a zero allocation.
"That is exactly the reason our Government reached an agreement to find 100 gigalitres from somewhere, to help supply water for local fodder and pasture growth during this coming summer and autumn; water which is outside of the existing allocations in NSW, Victoria and SA."
"I have been contacted by some constituents attending next week’s rally and look forward to meeting up with them while they are in Canberra.”
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