Khvicha Kvaratskhelia's dribbling wizardry and passing abilities befuddle defenders in Italy and beyond.
Individually, Osimhen and Kvaratskhelia are devastating enough. Together, they are leading Napoli to new heights game after game.
The latest demonstration came when Osimhen scored a brace of headers and Kvaratskhelia earned and converted a penalty and set up two goals in Napoli's 4-0 Serie A win at Torino on Sunday.
The victory moved the runaway leaders a staggering 19 points clear at the top and a step closer to Napoli's first league title since Diego Maradona led the club to their only two Italian championships, back in 1987 and 1990.
"There's a Neopolitan saying that goes, 'Whoever is hungry doesn't feel sleepy,' and that fits perfectly," coach Luciano Spalletti said.
"Once again they responded by showing that they're made of different stuff, that they know how to handle the Napoli shirt."
Osimhen started it off midway through the first half when he leaped above the defence to redirect in a corner with a towering header.
After a couple of key saves from Napoli goalkeeper Alex Meret, Kvaratskhelia doubled the advantage with a penalty.
Napoli's third goal was a full team move with Kvaratskhelia providing a backheel flick to Mathias Olivera, who floated in a cross for Osimhen to head in at the far post.
Osimhen has a league-best 21 goals in 27 matches, while Kvaratskhelia has 12 goals and 10 assists — the first player with such production in their first season in Europe's big five leagues since Diego scored 13 and provided 13 assists for Werder Bremen 16 years ago.
Kvaratskhelia also set up Tanguy Ndombole's first Serie A goal midway through the second half.
Lazio went second after beating Roma 1-0 and Inter Milan lost 1-0 at home to Juventus.
In Rome, fans clashed with police outside the Stadio Olimpico before the derby between Roma and Lazio.
The match was won through a Mattia Zaccagni shot midway through the second half. Roma had been reduced to 10 men in the first period when Roger Ibanez picked up his second yellow card for a foul on Sergej Milinkovic-Savic.
Having beaten Roma 1-0 in November, it is the first time Lazio have won both league derbies in 11 years.
At the San Siro, Serbia international Filip Kostic scored the winner as Juventus made it six victories from their past seven Serie A matches, and eight wins from 12 in the league since the turn of the year, with a 1-0 triumph over Inter.
A third defeat in four Serie A games dropped Inter to third, while Massimiliano Allegri's men move within nine points of the Nerazzurri.
Elsewhere, Fiorentina moved into the top half of the table by beating Lecce 1-0, while in the relegation zone, Sampdoria defeated Hellas Verona 3-1 with a brace from Manolo Gabbiadini.
That brought Sampdoria within four points of Verona, but the latter are five points from safety.
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