The 39-year-old British actress suffered aneurysms in 2011 and 2013 and has admitted to feeling haunted by the near-death experiences for years.
The brunette beauty - best known for playing Daenerys Targaryen in the HBO fantasy series Game of Thrones between 2011 and 2019, spoke to Variety about her health scares.
"For a number of years, I felt that I had cheated death, and it was coming to get me. I truly felt like I had done something wrong, and I shouldn't be here," she said.
"I also thought it ruined my ability to act - which some people might agree with!"
Clarke starred in Game of Thrones alongside the likes of Sean Bean, Richard Madden, Sophie Turner, Maisie Williams, Kit Harington and Rose Leslie.
The TV show proved to be a worldwide hit, but Clarke has denied earning a reported salary of $US300,000 ($A416,600) per episode.
"We didn't earn that much. Can you imagine? I'd have been driving a couple of Porsches," Clarke said.
She also confessed to struggling to cope with her own fame and success.
"I spent a lot of time trying to understand it. And then you realise it's just a formula: The less you're on TV, the less famous you are. It comes and it goes."
Meanwhile, Clarke previously sent her thanks to Britain's National Health Service workers who "saved [her] life" after she suffered a brain haemorrhage.
The London-born star wrote an open letter to the NHS to mark the institution's 72nd anniversary, thanking the staff who made sure she was never "truly alone".
"The memories I will hold dearest, though, are ones that fill me with awe: of the nurses and doctors I knew by name when, in the weeks after my first brain haemorrhage, we watched the passing of time and the passing of patients in the Victor Horsley Ward at the National Hospital for Neurology and Neurosurgery in Queen Square, London," she wrote.
"The nurse who suggested - Â after everyone else in A and E struggled to find an answer when I was first admitted - that maybe, just maybe I should have a brain scan. She saved my life."
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