The beloved Cheers actor's publicist confirmed news of his death on Tuesday, describing him in a statement as "a doting family man, a well-loved friend and confidant to all of those lucky enough to have known him" .
His family has requested privacy at this time.
Best known for his role as beer-swilling Norm Peterson on the hit NBC bar sitcom Cheers, Wendt had spoken candidly about the impact of the show on his life.
He said in a past interview: "I was lucky to be part of something that became such a beloved part of people's lives."
Born in 1948, Wendt became a household name throughout the run of Cheers, which aired for 11 seasons from 1982 to 1993.
Despite a rocky start with low ratings that nearly saw the show cancelled after its first season, the sitcom grew to become a defining sitcom of its era, spending eight of its remaining 10 seasons in the top 10 shows and peaking as the most-watched programme in its ninth season.
The series received 117 Emmy nominations, winning 28 awards, including Outstanding Comedy Series four times.
Wendt was nominated for six consecutive Emmys for his portrayal of Norm, appearing in every episode until the series ended in May 1993.
Born and raised in Chicago, the actor's path to stardom was unconventional.
He was expelled from the University of Notre Dame in Indiana due to poor grades before entering showbusiness.
His first job was sweeping floors at a theatre, but he soon landed guest roles in popular shows such as Taxi and M*A*S*H before securing his breakthrough part on Cheers.
After the sitcom ended, Wendt starred in a self-titled CBS sitcom in 1995, which was cancelled after eight episodes.
Outside of Cheers, Wendt appeared in various television roles including Sabrina The Teenage Witch and Columbo.
George was married to Bernadette Birkett, who voiced his never-seen sitcom wife Vera on Cheers, since 1978.
The couple had three children – a daughter and two sons.
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