Australia on Wednesday named 13 players for February's three-match home series, with the three frontline quicks and Mitch Marsh all rested.
Steve Smith will captain in place of Pat Cummins, while tearaway quick Lance Morris has been included and is set to make his long-awaited international debut.
Lance Morris looks set to make his long-awaited international debut for Australia. (Richard Wainwright/AAP PHOTOS)
Aaron Hardie, Matt Short, Jhye Richardson and Nathan Ellis have also been selected, after missing out on the squad that won last year's World Cup.
There is almost as much interest in who will not play on February 2, 4 and 6 in Melbourne, Sydney and Canberra in the first one-day international series since David Warner's retirement.
Stoinis is the biggest name to miss out, after playing six games in the World Cup before being squeezed out through Australia's desire to field a batter-heavy side.
Agar also drops out, despite returning to full fitness in the Big Bash League with Perth having missed the World Cup with a calf injury.
Ashton Agar is back at full fitness but has been rested for the one-dayers against West Indies. (Lukas Coch/AAP PHOTOS)
Alex Carey has been left to focus on his red-ball cricket, having been dropped for Josh Inglis after the first game of the World Cup campaign.
Australia have largely turned their eyes to Twenty20 cricket in the white-ball formats, with the 2025 Champions Trophy the only global tournament between now and the 2027 World Cup.
"Further opportunities for the likes of Aaron Hardie, Matt Short, Jhye Richardson, and Nathan Ellis will be valuable both to our ongoing improvement as a team and also further their personal experiences in ODI cricket," chief selector George Bailey said.
"The squad strikes a balance between players continuing to make their mark on international cricket, playing alongside some of our most experienced players with an eye to the future in this format."
Australia will also play three T20s against West Indies on February 9, 11 and 13, with a squad for those matches yet to be named.
AUSTRALIA SQUAD FOR WEST INDIES ODI SERIES:
Steve Smith (capt), Sean Abbott, Nathan Ellis, Cameron Green, Aaron Hardie, Travis Head, Josh Inglis, Marnus Labuschagne, Glenn Maxwell, Lance Morris, Jhye Richardson, Matt Short, Adam Zampa.