However Mr Andrews said the state was well-placed to reopen as scheduled, after it recorded two new locally acquired cases of COVID-19 on the fourth day of its snap lockdown.
But the Premier added it was "too early to make a definitive call" on whether Victoria would go back to the same set of rules in place before the lockdown.
The new cases are close household contacts of previously diagnosed cases connected to the Holiday Inn Melbourne Airport outbreak, and bring the total number of cases linked to the growing cluster to 19.
Victorian Premier Daniel Andrews said these new cases did not pose further risk.
"They've been isolating. They've been at home. They've done the right thing. They're not unexpected positives," he said.
"It is fair to say that with just two contained additional community cases today, this strategy is working."
Mr Andrews said the state was in a promising position to open as planned at midnight Wednesday, after the growing Holiday Inn cluster sparked a snap lockdown on Friday at midnight.
"As I said yesterday, I'm not in a position to definitively commit to that, because these next 24 hours will, of course, be crucial," he said.
"However, with a relatively small number of new cases, the excellent work that our contact tracing teams have done, the work of lab technicians and so many other people, we are very well placed."
The Premier also announced authorities were "actively pursuing and examining" the construction of a purpose-built quarantine centre, which would significantly replace the work of inner city hotels.
He said the centre would emulate the Northern Territory's Howard Springs facility, a disused worker's camp 25km out of Darwin which is being used to house people returning to Australia on government repatriation flights.
"It would be a cabin-style, village-style environment, where there would be fresh air, where there would be not zero risk but lower risk," he said.
Two further infections were also reported in hotel quarantine on Tuesday, after almost 24,000 test results were processed Monday.
This comes as the AstraZeneca COVID-19 vaccine was approved for use in Australia by the nation’s medical regulator, the Therapeutic Goods Administration (TGA) on Tuesday.
The vaccine will be used to immunise people aged 18 and over, with the immunisation of people aged over 65 to be decided on a case by case basis.
It’s expected the AstraZeneca rollout will kick off in early March, if not earlier, according to Federal Minister for Health Greg Hunt.
Most Australians will be offered this jab, with the bulk of the vaccine to be manufactured in Australia.
To see the full list of exposure sites linked to the Melbourne outbreak, visit dhhs.vic.gov.au/case-locations-and-outbreaks-covid-19
