It comes after the 48-year-old won best rap album for his sixth studio album, Michael, while his track Scientists And Engineers featuring Andre 3000, Future And Eryn Allen Kane won best rap song and best rap performance.
Killer Mike, real name Michael Render, is in the process of being released by the Los Angeles Police Department, a spokesperson said.
"On Sunday, February 4, just after 4pm, a male adult was detained and handcuffed for a physical altercation that occurred at the 700 block of Chick Hearn Court," a statement said.
"The suspect was placed under arrest and was transported to LAPD Central Division.
"The suspect has been identified as 48-year-old Michael Render and booked for misdemeanor battery ... and is in the process of being released."
Video footage posted to social media appeared to show the music star being detained, as a voice is heard saying: "are you serious? What the f***?".
Celebrating his Grammy wins on stage before his arrest, Killer Mike said "this is for all the people who think you're too old to rap ... we keep hip hop alive. Never ever stop doing what you do."
"You cannot tell me dreams do not come true."
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