Madeleine was three when she vanished while on a family holiday in Praia da Luz, Portugal, in 2007.
"The years appear to be passing even more quickly and whilst we have no significant news to share, our determination to leave no stone unturned is unwavering," a statement from her parents Kate and Gerry McCann and the family said.
On May 12, Madeleine would be turning 22.
"We continue to celebrate her as the very beautiful and unique person she is. We miss her."
The statement, posted on the Find Madeleine website, thanked supporters "for standing by us and never forgetting about Madeleine".
The family expressed gratitude to the UK charity Missing People for their ongoing, invaluable work.
In April, ministers approved more than £100,000 ($A205,926) in additional funding for Scotland Yard detectives investigating Madeleine's disappearance.
Madeleine was three when she vanished while her parents went to dinner with friends, leaving their three young children asleep in their holiday apartment.
Prime suspect Christian Brueckner, who is serving a seven-year prison sentence in Germany for the rape of an elderly woman at her home in the Praia da Luz in 2005, has denied any involvement in Madeleine's disappearance.
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