The simultaneous attacks represented the latest burst of violence since a surprise offensive by Israel two days earlier aimed at decimating Tehran's rapidly advancing nuclear program.
Iranian missiles entered Israel's skies in attacks that Israeli emergency officials said caused deaths around the country, including four in an apartment building in the Galilee region. A strike in central Israel killed an 80-year-old woman, a 69-year-old woman and a 10-year-old boy, officials said.
Casualty figures weren't immediately available in Iran, where Israel targeted Defence Ministry headquarters in Tehran as well as sites that it alleged were associated with the country's nuclear program. Iran's paramilitary Revolutionary Guard claimed that Iranian missiles targeted fuel production facilities for Israeli fighter jets, something not acknowledged by Israel.
Amid the continued conflict, planned negotiations between Iran and the United States over Tehran's nuclear program were cancelled, throwing into question when and how an end to the fighting could come.
Both Israel's military and Iran state television announced the latest round of Iranian missiles as explosions were heard near midnight, while the Israeli security cabinet met.
Israel's ongoing strikes have left Iran's surviving leadership with the difficult decision of whether to plunge deeper into conflict with Israel's more powerful forces or seek a diplomatic route.
World leaders made urgent calls to de-escalate and avoid all-out war. The attack on nuclear sites set a "dangerous precedent," China's foreign minister said. The region is already on edge as Israel makes a new push to eliminate the Iranian-backed militant group Hamas in Gaza after 20 months of fighting.
Israel said its hundreds of strikes on Iran over the past two days have killed a number of top generals, nine senior scientists and experts involved in Iran's nuclear program. Iran's UN ambassador has said 78 people were killed and more than 320 wounded.
US intelligence agencies and the International Atomic Energy Agency have repeatedly said Iran was not pursuing a nuclear weapon before Israel unleashed its campaign of airstrikes targeting Iran beginning Friday. But Iran's uranium enrichment has reached near weapons-grade levels, and on Thursday the UN's atomic watchdog censured Iran for not complying with obligations meant to prevent it from developing a nuclear weapon.
Prime Minister Benjamin Netanyahu, who has made the destruction of Iran's nuclear program his top priority, said Israel's strikes so far are "nothing compared to what they will feel under the sway of our forces in the coming days."
In what could be another escalation if confirmed, semiofficial Iranian news agencies reported an Israeli drone struck and caused a "strong explosion" at an Iranian natural-gas processing plant. It would be the first Israeli attack on Iran's oil and natural gas industry. Israel's military did not immediately comment.
The sixth round of US-Iran indirect talks on Sunday over Iran 's nuclear program will not take place, mediator Oman said.
Iran's top diplomat said Saturday the nuclear talks were "unjustifiable" after Israel's strikes. Abbas Araghchi's comments came during a call with Kaja Kallas, the European Union's top diplomat.
The Israeli airstrikes were the "result of the direct support by Washington," Araghchi said in a statement carried by the state-run IRNA news agency. The US has said it isn't part of the strikes.
On Friday, US President Donald Trump urged Iran to reach a deal with the US on its nuclear program, adding that "Iran must make a deal, before there is nothing left."
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