The Cats defeated Benalla 10.8 (68) to 6.4 (40), with Riley Moon starring with four goals.
Will McPhee was the other multiple goal-scorer, contributing two majors to the total.
Blake Booker and Will O'Donoghue were the best players for the Saints.
Shepparton United put Seymour to the sword, keeping the Lions to two goals for the match.
United won 17.9 (111) to 2.4 (16), with Kyle Montgomery (five goals), Jake Zerbato (four) and Ryan Calogero (three) kicking multiple snags in the victory.
Ty-Reece Morgan and Lucas Cannizzo were the Lions’ goal-kickers.
Echuca also had a field day against Euroa.
The Murray Bombers defeated the Magpies 18.12 (120) to 1.9 (15).
Cooper Willoughby kicked five majors and Elijah Bruns and Thomas Donchi contributed four each for the Murray Bombers.
Euroa's only goal was kicked by Ryan Spencer.
Four goals from Anthony Depasquale helped Kyabram defeat Tatura by 68 points.
The Bombers led at every change in the 18.8 (116) to 8.0 (48) triumph.
Liam Scopelliti and Bohden Learmonth each kicked three for the Bombers, while Blake Armstrong stood out with five goals for the Bulldogs.
Shepparton Swans had 11 different goal-kickers in their 80-point win over Mansfield.
The Swans won 16.18 (114) to 5.4 (34), with Steele Simpson leading all comers with five goals.
Billy Browne was the other multiple goal-kicker, scoring a brace of goals.
Charlie Christopher and Cody George also kicked two goals each for the Eagles.
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