With two rounds remaining in the season, the second-placed Lions sit equal on 52 points with Echuca (third) and face a tough task in battling Mooroopna (fifth).
The round 17 clash will be the second meeting between the clubs this season, following Seymour's dismantling of the Cats in round six.
However, Mooroopna has roared into premiership contention since.
From their past 10 rounds, the Cats have the second-best record in the league with eight wins, one loss and a draw since round six.
The most recent win for Di Hanslow's side was a 15-goal success against Tatura last Saturday.
Ash Lancaster recorded another brilliant performance in that triumph, with the shutdown defender enjoying another superb season.
However, Mooroopna's brick wall will have a tough assignment against Seymour shooting duo Jess Lallo and Ellie O'Sullivan.
Lallo starred in goals for the Lions in last weekend's tense two-goal win against Shepparton in wet and windy conditions.
Seymour coach Elle McDonald told the Seymour Telegraph that she was happy to walk away winners against the Bears, especially in the wild conditions.
‘‘We knew it was going to be a tough game,’’ McDonald said.
‘‘Both teams are preparing for finals, so we were happy to get the two-goal win, especially in those conditions.
"It (the weather) slowed us down in attack and defence.
‘‘Our aim was to keep possessions when it was raining, treasure the ball and get it to our goalers.’’
McDonald was aware of the upcoming challenge of playing the in-form Cats before finishing off against Kyabram in round 18.
‘‘Mooroopna have done really well recently, so that’s another challenging game this weekend,’’ she said.
‘‘And considering we drew with Kyabram last time, we’re looking to improve on that and get the four points this time around.’’