Wiggins died on Friday morning after battling bladder cancer for the past year, according to a statement released by his family on social media.
"D'Wayne's life was incomparable, and his music and service impacted millions around the world, including in his hometown of Oakland, California," his family said.
"He was a guitarist, producer, composer, philanthropist, mentor and founding member of Tony! Toni! Tone! He was deeply passionate about providing artist development and mentorship to emerging young musicians, helping to shape the early careers of many."
Wiggins was a vocalist and bass guitarist of the beloved R&B group, which included his brother Raphael Saadiq and their cousin Christian Riley.
The group became mainstays of the New Jack Swing movement, blending R&B, jazz and traces of gospel melodies.
The Oakland, California, natives burst onto the music scene with their 1988 debut album Who? with songs such as Baby Doll and Little Walter.
But it was their 1990 New Jack Swing-infused Feels Good record that gave the group mainstream success, peaking at number nine on Billboard's Hot 100 chart.
They released two more studio projects together, with party hits like Let's Get Down, featuring DJ Quik, and timeless slow jams including Whatever You Want, It Never Rains (In Southern California), (Lay Your Head on My) Pillow and Anniversary, a standard in the black music romance canon.
The blood relatives also could not predict how their success would affect their relationship.
The Tonyies went their separate ways after their fourth album, 1996's platinum-selling House of Music.
Fame, finances, miscommunication and creative differences were unsustainable for the group.
Wiggins and Riley toured under the group's name between 1998 and 2018, with Amar Khalil taking over lead singing duties.
Ultimately, through Saadiq's efforts, the group made amends and reunited for a tour in 2023.
