Reeling from their first loss in four rounds, the Saints bounced back with an 8.7 (55) to 5.4 (34) win in blustery conditions at RSEA Park on Saturday.
Pending other results in the round, the Saints (5-4) could rise from 12th on the ladder and finish in eighth to make their first finals appearance.
St Kilda will need to win their last match of the season against fellow finals hopefuls Carlton next weekend but there is still a chance of missing the top eight should other results not go their way.
One-time Brisbane premiership player Jesse Wardlaw (two goals) was electric in her first meeting with her old side and wasted no time to get on the scoreboard, drawing first blood to give St Kilda a hot start.
Jamiee Lambert (20 disposals, four clearances) and Georgia Patrikios (one goal, 18 disposals) went to work in the midfield, while Nat Exon, Ashleigh Richards, Tyanna Smith, Deanna Jolliffe and Ashleigh Richards were among the Saints' goalkickers.
With Brisbane unable to master the wind, Taylor Smith kicked the only goal in the first half despite attempts from Irish ace Orla O'Dwyer and AFLW debutant Bella K. Smith.
Trailing by 21 points at third-quarter time, the Lions were effectively ruled out of the contest when two successive 50-metre penalties against Ellie Hampson for a dangerous tackle gifted Smith a shot at goal.
Smith kicked truly despite the wind against her to seal the win for the Saints, backed up by another magnificent goal by Wardlaw just three minutes later.
Brisbane threatened to surge back with two quick goals from O'Dwyer and Dakota Davidson but the peril was quickly subdued by majors to Saints duo Jolliffe and Richards.
Ally Anderson was the shining light for Brisbane, celebrating her 75th game with 19 disposals and 12 contested possessions - she is the first player in the league to reach the 75-game milestone.
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