May, Jack Viney and Bailey Fritsch all return for the Demons for their game at the Gabba against a Lions side bolstered by the inclusions of skipper Dayne Zorko, Darcy Fort and former St Kilda backman Darragh Joyce.
Brisbane lost Keidean Coleman to injury and dropped Dylan Robertson and 19-year-old midfielder James Tunstill from the side that lost by 54 points to Port Adelaide in their season-opener.
Melbourne, after their impressive round-one win over the Western Bulldogs, dumped Adam Tomlinson, Bailey Laurie and last week's substitute Jake Melksham.
The Power included ex-skipper Travis Boak in their squad to meet Collingwood at the MCG on Saturday afternoon despite concerns about a fractured rib which sidelined him last week.
Port summoned defender Jason Burgoyne to a side missing Trent McKenzie because of an ankle injury while Francis Evans was omitted.
The Magpies replaced Jeremy Howe (broken arm) with former Adelaide Crows utility Billy Frampton.
Frampton's ex-side Adelaide recalled winger Lachie Sholl for their Saturday twilight home clash against Richmond and dumped fullback Jordon Butts.
The Tigers made three omissions from their team which drew first-up against Carlton with Jack Ross, Rhyan Mansell and Ben Miller all axed.
Richmond's Tylar Young will make his AFL debut at Adelaide Oval while ruckman Samson Ryan returns for his second game at the elite level.
The Bulldogs made four changes for their Saturday night clash against St Kilda with Rory Lobb and Adam Treloar both injured, and Jason Johannisen and Mitch Hannan dropped.
Hayden Crozier, Rhylee West and Riley Garcia all return to meet a St Kilda outfit missing injured pair Jimmy Webster and Jack Bytel but strengthened by the return of influential on-baller Seb Ross.
The Kangaroos recalled veteran ruck Todd Goldstein and Aidan Corr to replace Tristan Xerr (injured) and Aidan Bonar (dropped) for their Saturday night match against Fremantle, who axed forward Josh Treacy.
In Sunday's squads, GWS were heavily hit by injury with key players Josh Kelly, Lachie Whitfield and Harry Perryman all unavailable to meet West Coast.
Sydney's emerging star Chad Warner was named in an extended squad minus Lance Franklin (suspension) for their encounter against Hawthorn, who lost Chad Wingard to a calf complaint.
Essendon, without Anthony McDonald-Tipungwuti (thigh) for Sunday's clash against Gold Coast, named Will Snelling and Kaine Baldwin among four inclusions.
The Suns dropped Alex Davies, with Lachie Weller and Alex Sexton among their inclusions before squads are finalised on Friday night.
2°C