Scans have shown Henry has a mid-foot lisfranc ligament injury after he was stood on during Saturday night's home win over Port Adelaide.
It is different to the foot fracture he had during the pre-season, which sidelined him until round 10.
The Cats are unclear how long Henry, who has played 11 games this season, will be out of action.
"We were surprised to see the results of the scans as the incident occurred innocuously during the game," said club football boss Simon Lloyd.
"Our medical team will now work through the options available to provide the optimal outcome for Jack and determine how long he will be sidelined for.
"We are all disappointed for Jack, he is a very important player for us, not just with his flexibility to play a number of roles, but because of his calm head and stability he provides down back."
Gary Rohan (ankle) is expected to play in Friday night's blockbuster against Collingwood, while Tom Hawkins ran laps on Tuesday and is expected to train on Wednesday as he returns from a hamstring injury.
Adelaide announced utility Chayce Jones will have surgery on a lisfranc fracture and is out for the rest of the season.
Melbourne utility Harrison Petty was sidelined by a lisfranc injury in Sunday's win over North Melbourne and it is unclear when he will return.
8°C