Second seed Sakkari powered past Dolehide, who is ranked 111th in the world, for a 7-5 6-3 victory to capture her second career title, ending the week without dropping a set.
Sakkari had lost six finals since winning her first title at the WTA 250 tournament in Rabat in 2019. She finished runner-up to Jessica Pegula in Guadalajara last year.
"We've heard so many bad things - that I will never win a title, that I'm a top-five player with only winning one title," said Sakkari, who broke down in tears after her win.
"That was very hard for me to overcome and I'm so happy that I did it here this week ... I want to thank my coach Tom who has been with me the last five years. We've waited for more than four years for a second title."
In Saturday's final, Dolehide rallied from a break down in a tight opening set to take a 5-4 lead, but Sakkari won the next three games to take the set.
She broke for a 3-2 lead in the second set and held for 5-3 with her third ace of the contest, before clinching victory after an hour and 43 minutes.
Sakkari, currently ranked ninth in the world, is expected to climb up to sixth when the rankings are updated on Monday.
Dolehide, 25, is set to break into the top 50 for the first time.
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