Former Roland Garros runner-up Tsitsipas outclassed Austrian qualifier Sebastian Ofner 7-5 6-3 6-0 on Sunday to set up a quarter-final showdown with top seed Alcaraz, where he will hope to seal a first win over the Spaniard in their fifth meeting.
"The clash we've been all waiting for. Everyone was expecting it, weren't they? It's here. It's game on," Tsitsipas, who had described Alcaraz as a breath of fresh air to tennis for his charisma and constant smiles, told reporters.
Tsitsipas' most recent meeting with the 20-year-old Spanish star was on the clay courts of Barcelona, where he was comprehensively beaten 6-3 6-4.
The Greek fell to a three-set defeat at the same venue a year earlier.
"Carlos is someone that keeps the intensity high at all times. He's someone that's not going to give you gaps where his attention isn't there," Tsitsipas said.
"He's very hyper. He's very energetic and you can see that on the court.
"He adds a lot of that into the rallies, into his rituals when he is out there playing the game. He has a lot of that when he plays. It has helped him a lot.
"He has that smile that he said obviously helps him a lot.
"Right now he's one of the biggest obstacles and challenges for any player to compete against. It pushes us all to be better."
