But coach Graham Arnold has opted against starting livewire attacker Riley McGree for Saturday night's high-stakes Group B clash at the Jassim bin Hamad Stadium in Doha, which kicks off at 10.30pm (AEDT).
With victory, Australia can seal progression to the round of 16 from Group B with a game to spare, before Uzbekistan and India face off at 1.30am on Sunday (AEDT).
Bos, who scored his first international goal in the opening group match, has replaced veteran Craig Goodwin on the left wing as one of three changes between matches.
Arnold has also turned to Cameron Burgess to partner Harry Souttar in defence, opting for the towering Ipswich Town man instead of Kye Rowles, while Aiden O'Neill replaces Keanu Baccus in midfield.
O'Neill, Jackson Irvine and Connor Metcalfe will be tasked with trying to break down what shapes as a deep-lying Syria defence.
Mitch Duke will lead the line on his 33rd birthday, though Bruno Fornaroli shapes as a likely inclusion off the bench, especially if the Socceroos are chasing a goal.
Third-choice goalkeeper Lawrence Thomas, defender Nathaniel Atkinson and striker John Iredale are the three players left out of the 23-strong match-day squad.
SOCCEROOS STARTING LINE-UP AGAINST SYRIA
Mat Ryan (GK) (C), Gethin Jones, Harry Souttar, Cameron Burgess, Aziz Behich; Aiden O'Neill, Jackson Irvine; Connor Metcalfe, Jordan Bos, Martin Boyle, Mitch Duke.
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