The Gunners had raced into a three-goal first-half lead at the Tottenham Hotspur Stadium on Monday (AEST) as Pierre-Emile Hojbjerg's own goal was added to by a Bukayo Saka strike and Kai Havertz header.
The hosts had seen a Micky van de Ven leveller ruled out by a marginal offside VAR call but rallied after the break, pulling one back as Cristian Romero took full advantage of a David Raya mistake before a late Son Heung-min penalty set up a grandstand finish.
Arsenal survived to complete a north London derby double for the season and ensure they would remain top of the table until at least next Saturday.
Mikel Arteta enjoys the applause from Gunners fans after their derby win. (AP PHOTO)
Having led the way for so long last term before eventually being caught and passed by a Manchester City side en route to winning the treble, Arteta feels this win and the likes of a 5-0 thrashing of Chelsea in midweek proves Arsenal have learnt from the experience.
"I think so," the Spaniard replied when asked if Arsenal are better equipped to win the title this time around.
"Last season we didn't because we went to West Ham and we missed a penalty and against Liverpool we conceded in the 91st minute and then you're not capable.
"We want to be better. There are margins for improvement. Go again against Bournemouth because it's going to be really tough."
Defeat for Tottenham damages their hopes of a top-four finish, with boss Ange Postecoglou left frustrated by the officiating.
Dejan Kulusevski saw a penalty shout waved away just seconds before Arsenal doubled their lead.
The fact a VAR intervention was then required to award Spurs' second-half spot kick after Declan Rice kicked Ben Davies only added to the complaint.
Ange Postecoglou is not too pleased with a decision during his latest London derby. (AP PHOTO)
"It doesn't matter how I saw it," said Postecoglou.
"What matters is what I've said all along, games are not refereed in the stadium any more. They are refereed somewhere else and no one will convince me otherwise.
"That's why I don't celebrate goals any more. I wait for somebody down the road. I just don't think referees in the stadium any more have that authority they used to to make decisions.
"They just go 'you know what, I'll just wait and see what the bloke down the road thinks'. It's a shame. I don't like it but it's here to stay and I've got to accept it like everyone else.
"The outcome was disappointing. We wanted to win today for our supporters and for the club. We didn't do that and whatever I think about the performance it's still the outcome that sits on you. I thought our general football was good, was decent."
