Chelsea beat Ajax in first leg of WCL quarter-finals

Chelsea's Lauren James
Chelsea's Lauren James scores her side's first goal past Ajax keeper Regina van Eijk. -AP

Chelsea beat Ajax 3-0 away in the first leg of the Women's Champions League quarter-finals to close in on a second straight appearance in the last four of Europe's top competition.

England forward Lauren James opened the scoring on Tuesday (local time) and Germany midfielder Sjoeke Nusken added goals either side of halftime for Chelsea, who are bidding to win the Champions League for the first time.

The second leg is at Stamford Bridge on March 27.

The London club is chasing a quadruple of major trophies in coach Emma Hayes' final season in charge before she takes the helm of the US women's national team.

Chelsea, despite Aussie superstar Sam Kerr being on the sidelines because of injury, lead the Women's Super League, are into the final of the English League Cup and have reached the quarter-finals of the FA Cup.

Ajax are competing in the knockout stage of the Champions League for the first time and caused plenty of problems for Chelsea early on at Johan Cruyff Arena, only to concede goals from the visitors' only two shots of the first half.

James rounded the goalkeeper and slotted home in the 19th minute for a goal that stood after a VAR check for offside, before Nusken slid in to convert the second in the 44th minute.

Nusken headed in the third goal in the 83rd minute to leave Chelsea in total control.