After a drenching 3-3 draw with Inter Milan in a magnificent semi-final first leg in the Champions League on Wednesday, the Catalans will resume their run for the league title against a struggling Valladolid squad on Saturday.
Valladolid look like the perfect opponents for Barcelona coach Hansi Flick, so weak that he can probably afford to rest some of his top players ahead of next week's second leg against Inter in Italy.
Last-placed Valladolid, owned by former Brazil great Ronaldo, have already been relegated, having lost 13 of their last 14 games, including seven in a row.
Valladolid have conceded 81 goals — 28 more than any other team - and face a Barcelona team known for their attacking prowess, having scored 89 league goals this season — 23 more than any other team.
With the three against Inter on Wednesday, Barcelona reached 158 goals in 54 games to become the fifth-highest scoring team in the club's history, equalling the marks set by the Barcelona squads in 2008-09 and 2012-13.
The 2011-12 squad, when Lionel Messi was in his pomp, remain far ahead after having scored a whopping 190 goals that season.
"We play with style and confidence, and we know what we can do," Flick said ahead of the trip to Valladolid.
Barcelona, seeking a treble of titles in their first season under the German, will be without defender Jules Kounde for a while after he sustained a left hamstring injury in the match against Inter.
Real Madrid, the defending champions, will try to remain in contention when they host seventh-place Celta Vigo on Sunday. Currently second, they trail Barcelona by four points with five to play.
They're enduring a slump that included being eliminated by Arsenal in the Champions League quarter-finals and losing to Barcelona in the Copa del Rey final.
Madrid have all their focus on the league now, where they've won three in a row and will face Barcelona in the Clasico a week on Sunday.
In other matches, third-placed Atletico Madrid visit relegation-threatened Alaves on Saturday, while fourth-placed Athletic Bilbao visit Basque Country rivals Real Sociedad on Sunday. Fifth-placed Villarreal host Osasuna on Saturday.
In the fight against relegation, 16th-placed Girona host mid-table Mallorca on Monday, while 19th-placed Leganes visit 15th-placed Sevilla on Sunday. Las Palmas, sitting 18th, host 14th-placed Valencia on Saturday.