In their last regular-season game, the Renegades are poised to end a four-year finals drought after a much-improved campaign.
Aaron Finch's team can lock in third spot if they take care of the Strikers at Marvel Stadium.
However, the Renegades will face a desperate Adelaide side who need to win to sneak into the top five.
Fast bowler Kane Richardson and veteran spinner Fawah Ahmed are back in the team after missing the 10-run defeat to reigning champions Perth on Sunday.
The Strikers enter the match in horrible form after dropping their last four games, with their last victory coming against the Renegades at Adelaide Oval on January 10.
MELBOURNE RENEGADES: Shaun Marsh, Martin Guptill, Sam Harper, Aaron Finch (capt), Matt Critchley, Jon Wells, Will Sutherland, Tom Rogers, Corey Rocchiccioli, Kane Richardson, Fawad Ahmed.
ADELAIDE STRIKERS: Matt Short, Travis Head, Alex Carey, Adam Hose, Colin de Grandhomme, Ryan Gibson, Harry Nielsen, Cameron Boyce, Wes Agar, Harry Conway, Peter Siddle.
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