Wilson, as well as winger Tim Ryan (ankle) and replacement flyhalf Harry McLaughlin-Phillips (HIA) were all late casualties in a 52-7 win on Saturday night at Suncorp Stadium.
Test flanker Wilson had returned from a fractured arm last week but coach Les Kiss believed this concern was a knock on his opposite wrist.
All three will be monitored on Sunday and remain in the mix for Friday's sudden death quarter-final against the Crusaders in Christchurch.
It was a tussle locked in before a ball was kicked on a soggy Saturday night in Brisbane, after other results had ensured the teams wouldn't budge from their second and fifth places respectively.
"It does put a dampener on a couple of things," Kiss said.
"It was pretty complete … for a game that really had no bearing on anything really it was us developing the type of game we're good at.
"We just get on with the business."
Anderson scored three times inside 10 minutes while the Drua were a man down in the first half, then added another before the main break to set a new mark for the Reds.
He's only the third Australian to score four tries in a Super Rugby game, after Joe Roff in 1996 and Drew Mitchell in 2010.
Most were handed to Anderson on a platter, especially a neat cross-field kick from clinical flyhalf Tom Lynagh for his fourth.
But the haul was just reward for a fine season from the former rugby sevens and Melbourne Rebels recruit.
Test centre Josh Flook also scored in his confident return from a long-term hamstring injury.
If Ryan is fit to play, Kiss will have a tough call to make on his backline, with red-hot Filipo Daugunu surely starting in the centres or on a wing next week after coming off the bench on Saturday night and scoring a late try.
Joe Brial completed the rout with a try on the full-time siren.
"I played sevens with him, seen his journey and how far he's come. He's shown he's a true, class winger," Reds captain Tate McDermott said of Anderson.
"A rock defensively and he's quick.
"Hopefully he gets a bit of credit and let's get him some more tries next week."
The Suva-based Drua won four games on home soil, including their clash with the Reds, but weren't able to muster a victory on the road as they finished second-last in their fourth campaign.
They had themselves to blame after an encouraging start, with Iosefa Masi yellow carded for up-ending Jock Campbell in the ruck and then Etonia Waqa binned in the second half for taking out Tim Ryan's legs in the air.
Haereiti Hetet scored their sole try while hooker Tevita Ikanivere, in his 50th game for the fledgling Drua, was denied from a trick play from the lineout.
He charged through two would-be tacklers only to be sent into touch by a flying Lynagh, who again showed defensive grit to go with offensive flourish.
"We have a lot of faith in Tevs and Isoa Nasilasila as well," coach Glen Jackson said of the Drua pair first to the 50-game milestone.
"They're the two guys who've shown week in, week out what it means to play for the Drua."
