The match was shortened to 14 overs per side after showers held up play by 65 minutes on Tuesday night.
But the game started in clear conditions and boasted a healthy crowd.
The Renegades made two changes, with in-form spin bowler Mujeeb Ur Rahman sidelined because of a contract dispute with the Afghan cricket board.
It is unclear whether Mujeeb will play for the Renegades again this season.
Joe Clarke is out because of a leg injury, with Jordan Cox playing his first BBL game of the season and Kane Richardson also returning.
Out-of-form captain Nic Maddinson remains sidelined and Will Sutherland will lead the Renegades.
The Stars dropped Corey Rocchiccioli for Jono Merlo.
The late-afternoon rain prompted a cheeky post on X from the Renegades, whose home ground is Marvel Stadium.
"Bit wet, but likely to clear This wouldn't have happened if there was a roof, btw," they posted.
Captain Glenn Maxwell will play his 100th game for the Stars, the first player to reach that milestone at the team.
STARS: Glenn Maxwell (capt), Tom Rogers, Dan Lawrence, Beau Webster, Marcus Stoinis, Hilton Cartwright, Imad Wasim, Jono Merlo, Sam Harper, Joel Paris, Mark Steketee.
RENEGADES: Will Sutherland (capt) Quinton De Kock, Jordan Cox, Jake Fraser-McGurk, Shaun Marsh, Jon Wells, Mackenzie Harvey, Tom Rogers, Adam Zampa, Kane Richardson, Peter Siddle.
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