The Hurricanes won the bat flip and chose to bat first at University of Tasmania Stadium in Launceston on Monday night.
Overseas signings Anderson (New Zealand), Jordan and Hain (both England) and Perth Scorchers recruit Hatzoglou play their first match in Hurricanes colours.
The Sixers, who opened their campaign with an eight-run victory over the Renegades on Friday, made two changes.
Daniel Hughes replaces Steve Smith, who is on Test duty after notching a player-of-the-match 42-ball 61 against the Renegades.
Quick Sean Abbott is sitting out because of family reasons, with his spot taken by off-spinner Todd Murphy.
Hurricanes quick Nathan Ellis will lead the side after taking over from Matthew Wade as skipper.
HURRICANES: Matthew Wade, Caleb Jewell, Ben McDermott, Sam Hain, Tim David, Corey Anderson, Chris Jordan, Paddy Dooley, Nathan Ellis (c), Riley Meredith, Peter Hatzoglou
SIXERS: James Vince, Josh Philippe, Daniel Hughes, Moises Henriques (c), Jordan Silk, Tom Curran, Jack Edwards, Ben Dwarshuis, Jackson Bird, Todd Murphy, Stephen O'Keefe.
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