After winning the bat flip in Launceston, opener Caleb Jewell (42 from 24) got Hobart off to a flyer before the wheels fell off after the powerplay.
Sixers seamer Tom Curran (3-19) started the damage when he had Jewell caught at mid-off in the sixth over.
Fellow quick Ben Dwarshuis (2-21) then picked up England import Sam Hain and Australia representative Tim David for single figures in his first over.
Young allrounder Jack Edwards got in on the action, with wicketkeeper Philippe snaffling a one-handed diving catch at full stretch to grab the edge of Ben McDermott.
Hobart fell to 5-69 in the ninth over before Chris Jordan (16 from 21) and Corey Anderson (17 from 27) stemmed the bleeding.
Batting at No.8 Paddy Dooley chipped in with an 18-ball 19 late in the innings.
Edwards finished with 2-18 from four overs, while Jackson Bird also picked up a scalp.
The Sixers are without Steve Smith (Test duties) and Sean Abbott (family reasons) from their season-opening eight-run win over the Renegades on Friday.
Overseas signings Anderson, Jordan and Hain, as well as Peter Hatzoglou (Perth Scorchers), are playing their first game in Hurricanes colours.
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