Green birdied the last three holes and drained a pressure-cooker 30-foot uphill putt at the 72nd hole on Sunday to snatch victory from would-be world No.1 Celine Boutier.
The 27-year-old closed with a third straight five-under-par 67 to win by a shot at 13 under from Boutier, the French world No.3 who would have usurped American Lilia Vu for the top ranking had she won.
Boutier also carded a closing 67.
Green, the 2019 US Women's PGA champion, joins Karrie Webb, Jan Stephenson, fellow Perth star Minjee Lee and Rachel Hetherington as only the fifth Australian to win at least five times on the LPGA Tour.
As well as soaring into the top 10 on the LPGA's season-long Race to Globe points list, Green follows Webb, the nation's most prolific major championship winner, as a victor in this prestigious $US1.8 million, no-cut tournament.
Her latest triumph also served as redemption of sorts after Green suffered a heartbreaking runner-up finish at Sentosa Golf Club previously.
"A few years ago, I almost had this trophy on my hands and made two bogeys coming down the last (stretch), so it's almost like it was meant to be today for me holing those two putts on the last two holes," Green said..
"I'm so happy to have this in my hands."