Australia are playing their first match on home soil in nine months after winning the ICC Women's T20 World Cup and retaining the Ashes against England in that time.
Healy becomes just the third woman to play 250 games for Australia across all formats, while Megan Schutt lines up for her 100th T20I.
Australia's long-serving skipper Meg Lanning is not part of the squad to play West Indies, with Healy taking the reins for the three T20Is and three ODIs in the series after also doing so for the Ashes.
Ellyse Perry returns to the side after injuring a knee against Ireland in July but it remains to be seen whether the gun all-rounder will bowl.
Hayley Matthews leads a West Indies outfit that has named several emerging prospects alongside more experienced performers like Stafanie Taylor and Shemaine Campbelle.
The West Indies are playing under the guidance of Shane Deitz for the first time as the former South Australia wicketkeeper-batter takes on the role as their head coach.
Australia: Alyssa Healy (c), Tahlia McGrath (vc), Darcie Brown, Ashleigh Gardner, Jess Jonassen, Phoebe Litchfield, Beth Mooney, Ellyse Perry, Megan Schutt, Annabel Sutherland, Georgia Wareham.
West Indies: Hayley Matthews (c), Aaliyah Alleyne, Shemaine Campbelle (vc), Shamilia Connell, Afy Fletcher, Chinelle Henry, Shabika Gajnabi, Zaida James, Karishma Ramharack, Stafanie Taylor, Rashada Williams (wk).
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