Deputy District Attorney John McKinney said during his opening statement there was "no doubt" Eric R Holder knew in advance that he would kill Hussle.
The prosecutor described the sequence of events, including the talk about "snitching", before Hussle's shooting death three years ago in the South Los Angeles neighbourhood where both men grew up.
Two others were wounded in the shooting.
As well as shooting Hussle at least 10 times, Holder kicked the rapper in the head before fleeing, McKinney told the Los Angeles courtroom on Wednesday.
"He clearly thought about what he was going to do before he did it," McKinney told jurors about Holder's intentions.
Holder, 32, faces one count of first degree-murder and two counts of attempted first-degree murder.
Hussle, a hip-hop artist, father of two, and widely beloved South LA local born Ermias Asghedom, was shot and killed at age 33 on March 31, 2019, in the car park outside his store, known as The Marathon.
McKinney said Holder and Hussle knew each other, growing up in the same neighbourhood where they were members of the same gang, the Rollin' 60s.
Attorney Aaron Jansen has a formidable task in defending Holder, who could get life in prison if convicted. Multiple witnesses who knew both Holder and Hussle told police and grand jurors that Holder walked up to Hussle and gunned him down.
Jansen has said the killing of Hussle was not premeditated, and the shooting of the other two men was not intended at all, making the first-degree murder and attempted murder charges excessive. He is also likely to make Holder's mental health an issue.
Jansen said on Wednesday that Holder was triggered and did not have time to cool off before he gunned down Hussle saying this is a case of "heated passion".
