Lobb hurt his shoulder during last week's loss to Sydney and he failed to make the trip to Melbourne to take on the Tigers.
His absence means swingman Griffin Logue is set to play as a forward, with returning backman Alex Pearce to hold the fort in defence.
The Dockers also recalled speedster Liam Henry in place of axed veteran Travis Colyer.
Richmond welcome back premiership ruckman Ivan Soldo, who missed last week's shock loss to North Melbourne with a fractured thumb.
Brisbane have welcomed back skipper Dayne Zorko, Daniel Rich, Jarrod Berry, Marcus Adams and Oscar McInerney for Saturday night's QClash with Gold Coast, but in-form defender Keidean Coleman goes out through injury.
Gold Coast have also made five changes with Elijah Hollands named for his AFL debut, and Jy Farrar, Jeremy Sharp, Rory Atkins and Darcy MacPherson all recalled.
The axe fell on Jack Bowes, Brayden Fiorini, Oleg Markov, Sam Day and Hewago Oea.
The Saints axed Zac Jones and Nasiah Wanganeen-Milera for Sunday's match against West Coast following last week's insipid loss to the Western Bulldogs, while ruckman Paddy Ryder (calf) could miss the rest of the season.
Seb Ross and Hunter Clark are among the inclusions.
GWS will make at least five changes for Sunday's match against Carlton at Marvel Stadium, with Jesse Hogan (rested), Josh Kelly (concussion), Connor Idun (broken foot) and Tom Green (rested) among the outs.
Braydon Preuss and Adam Kennedy have both been named in the starting line-up.
The Blues will be without injured midfielder George Hewett (back) and the suspended Will Hayes, but defender Mitch McGovern is a chance to return after being named in the extended squad.
