Hooker Keeley Davis is the only member of the spine to have played in last year's 8-6 Origin loss.
Rachael Pearson will make her Origin debut at halfback, joined by her St. George Illawarra teammate, fullback Emma Tonegato.
Five-eighth Kirra Dibb joins the halves pairing and will play her first Origin match since 2019.
Hilder's changes came after incumbent fullback Botille Vette-Welsh tore her ACL playing for Parramatta in the final round of the NRLW premiership.
Last year's halfback and former Origin captain Maddie Studdon missed out on selection in the extended squad, while five-eighth Corban Baxter was named a reserve.
Sydney Roosters second-rower Olivia Kernick and Newcastle Knights prop Caitlan Johnston will make their debuts from the bench.
Alongside Dibb, Hilder has recalled Shaylee Bent and Sam Bremner, the only member of the Origin side without an NRLW contract.
Eleven of the 17 named played in the 2021 NRLW Grand Final for either the Dragons or Sydney Roosters.
Dragons prop Kezie Apps will captain the side for the fourth time.
From next year onwards, the women's Origin will be expanded from a one-off match to a two-game series.
Should the 2023 series end in a tie, the winner of this year's match will retain the shield.
NSW's women' State of Origin team
1. Emma Tonegato (St George Illawarra Dragons)
2. Yasmin Clydsdale (Sydney Roosters)
3. Jess Sergis (Sydney Roosters)
4. Isabelle Kelly (Sydney Roosters)
5. Tiana Penitani (Parramatta Eels)
6. Kirra Dibb (Newcastle Knights)
7. Rachael Pearson (St George Illawarra Dragons)
8. Simaima Taufa (Parramatta Eels)
9. Keeley Davis (St George Illawarra Dragons)
10. Millie Boyle (Newcastle Knights)
11. Kezie Apps (c) (St George Illawarra Dragons)
12. Shaylee Bent (St George Illawarra Dragons)
13. Hannah Southwell (Newcastle Knights)
14. Quincy Dodd (St George Illawarra Dragons)
15. Sarah Togatuki (Sydney Roosters)
16. Caitlan Johnston (Newcastle Knights)
17. Olivia Kernick (Sydney Roosters)
18. Sam Bremner (Cronulla Sharks - NSW Women's Premiership)
19. Teagan Berry (St George Illawarra Dragons)
20. Filomina Hanisi (Parramatta Eels)
21. Talei Holmes (St George Illawarra Dragons)
22. Corban Baxter (Sydney Roosters)
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