The Rebels dominated the opening exchanges and scored first, after already being denied what appeared a clear try.
But the hosts then dominated, winger Ivania Wong bagging a hat-trick and prop Liz Patu a double, her first a monumental run to the line after returning from the sin-bin.
Their bonus-point victory pushed them within a point of second-placed NSW Waratahs, who lost for the first time in Super W history to unbeaten Fijiana Drua on Friday night.
The Waratahs will play the Reds next week before they line up again in a semi-final, the winner to take on the Drua in the decider.
Saturday's Women in Rugby round was made special by the gathering of a host of former Reds players, who formed a guard of honour pre-game and then celebrated on full-time.
They were on hand to receive their Reds caps alongside current players, the eight-month project orchestrated by Vanessa Bradley documenting 26 years of rugby history and identifying 238 Queensland representatives since the first capped match in 1996.
"They came out to play and we were a bit spooked," Reds captain and Rio Olympic rugby sevens gold medallist Shannon Parry said.
"We toughed it out there in the breakdown ... started to set the platform, doing the grind work so the backs could get those glory tries."
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