Shepparton Highway Patrol officers ran the operation between March and June, with 124 drivers receiving a penalty notice or a date at court for driving offences.
Police detected 78 speeding drivers, including six motorists allegedly travelling more than 25km/h over the limit, which carries an automatic licence suspension.
Nine drivers tested positive for drugs, with one driver also returning a blood alcohol level over the limit of 0.05.
Police also caught 16 people driving while holding a disqualified, suspended or cancelled licence, four drivers not wearing seatbelts, and three motorists using mobile phones while driving.
Three vehicles were impounded, and 12 defect notices were issued.
Highest speeds recorded across Greater Shepparton include:
A 48-year-old Cosgrove man was recorded allegedly travelling at 143km/h in a 100km/h zone on the Midland Hwy.
A 31-year-old Merrigum man was recorded allegedly travelling at 140km/h in a 100km/h zone on MacIsaac Rd.
A 34-year-old Mooroopna man was recorded allegedly travelling at 129km/h in a 100km/h zone on MacIsaac Road.
A 39-year-old Kialla man was recorded allegedly travelling at 113km/h in a 60km/h zone on River Rd, Shepparton.
A 71-year-old Mooroopna woman was recorded allegedly travelling at 107km/h in an 80km/h zone on the Midland Hwy.
A 32-year-old Grahamvale man was recorded allegedly travelling at 90km/h in a 60km/h zone on Grahamvale Rd.
Shepparton Highway Patrol Sergeant Janne Kennedy said it was “absolutely staggering” that some drivers thought it was acceptable to drive at high speeds on Victorian roads, saying it was a “blatant disregard for human life”.
“People who drive like this are gambling with lives — theirs and everyone else’s on the road,” she said.
“If you’re caught driving at these speeds, you can expect to lose your licence, your car, and in many cases, face court.
“We want everyone to get home safely, and we’ll continue doing everything we can to keep dangerous drivers off our roads.”
Anyone with information about unsafe or illegal driving is urged to contact Crime Stoppers on 1800 333 000 or submit a confidential report at crimestoppersvic.com.au