The band - who haven't performed together since 1984 and officially disbanded in 1991 - had been teasing an announcement and on Thursday, they shared the first video for their 1977 single Psycho Killer, which features actress Saoirse Ronan.
The new clip is directed by Mike Mills and shows a young woman moving through her daily routine at her home, office and car, each day becoming a different version of herself.
Mills declared the video to be one of "the best" projects he's been involved with.
He said: "This album literally changed what was possible in life for me, so to get to play with the subversive, uncategorisable beauty of Talking Heads, and to play with Saoirse who brought so much surprise, power, vulnerability and mischief to the party, it's one of the best things I ever got to be a part of – still can't believe it actually happened."
And Talking Heads - David Byrne, Tina Weymouth, Jerry Harrison, and Chris Frantz - are delighted with his work.
They said in a statement: "This video makes the song better- We LOVE what this video is NOT – it's not literal, creepy, bloody, physically violent or obvious."
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