The Queen of Pop revealed on Instagram that she has been working with producer Stuart Price in London on new material that is set to be released next year.
In a caption accompanying a video, Madonna wrote: "Working on new music with Stuart Price. These past few months has been medicine for my SOUL.
"Songwriting and making music is the one area where I don't need to ask anyone for their permission. I'm so excited to share it with you. Who wants to hear new music in 2025?"
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The 66-year-old collaborated with Price on her acclaimed 2005 album Confessions on a Dance Floor as well as her recent Celebration Tour - which is said to have "reignited the spark" for the singer to make new music.
A source told The Sun newspaper in Britain: "Stuart was credited with helping Madonna return to form with their Confessions album, so for her to start working again with him is hugely exciting.
"That record was incredible and Madonna is excited about what they can come up with.
"It has been five years since she released Madame X, which was a concept album and Madonna is ready to put down some new tunes.
"Working with Stu on her tour reignited the spark. She has fire in her belly and cannot wait to get started."