Englishman Tom Curran is back for the Sixers after serving his suspension for intimidating behaviour towards an umpire.
The Heat are unbeaten and the Sixers have lost just once this season.
The Sixers have had their past two matches ruined by rain, including the New Year's Day clash with the Heat in Brisbane.
SYDNEY SIXERS: James Vince, Josh Philippe, Kurtis Patterson, Moises Henriques (capt), Jordan Silk, Tom Curran, Jack Edwards, Sean Abbott, Ben Dwarhuis, Todd Murphy, Stephen O'Keefe.
BRISBANE HEAT: Colin Munro (capt), Josh Brown, Matthew Renshaw, Sam Billings, Nathan McSweeney, Paul Walter, Michael Neser, Xavier Bartlett, Spencer Johnson, Mitch Swepson, Matt Kuhnemann.
8°C