Temperatures will drop to below minus 40C in parts of the northeastern province of Heilongjiang and in the region of Xinjiang in the northwest, along with Inner Mongolia and the provinces of Gansu and Qinghai, according to forecasts from China's National Meteorological Centre.
The cold wave that began the start of this week is moving through the country from north to south and is expected to drag temperatures lower into the weekend even as the Meteorological Centre says rain and snow will decrease.
The city of Yichun in Heilongjiang could see a January 1980 record of minus 47.9C be broken early next week as severe weather conditions set in.
In Henan province, snowfall and icy roads along with heavy fog caused multiple accidents on several expressways leading to traffic controls.
Traffic authorities in Ningxia province said some of its highways have become unsafe and implemented temporary traffic measures as snow fell. Neighbouring Gansu also saw some highways closed and trains suspended, according to state media.
Ferries and some buses were temporarily suspended early on Friday in Shanghai as the financial hub issued its first cold wave warning of the year as cold air from the north is forecast to reduce temperatures to as low as minus 6C this weekend.
In the southwest, sections of many national and provincial highways in Tibetan cities such as Shigatse and Nyingchi were blocked due to snow, ice and low visibility as the skies have dumped snow since Monday.
China lifted its warning for blizzards before dawn on Friday but said heavy snowfall is forecast in parts of Liaoning and Jilin provinces in the northeast as well as in Shandong.
The national forecaster said the scope and intensity of freezing rain will decrease on Friday but will still appear in some higher terrains in Guizhou and Hunan.