Perry, 54, was found at a Los Angeles-area residence on Saturday after authorities rushed to a call over a cardiac arrest, emergency sources told the publication.
Perry was found in a jacuzzi with no sign of foul play, a law enforcement source told the Los Angeles Times.
Asked by AP to confirm a police response to what was listed as Perry's home, LAPD officer Drake Madison told The Associated Press that police had gone to the Pacific Palisades neighbourhood of Los Angeles "for a death investigation of a male in his 50s."
There were no drugs at the scene, according to celebrity website TMZ.
Perry was best known for his role as Chandler Bing on all 10 seasons of Friends, starring opposite Jennifer Aniston, Courteney Cox, Matt LeBlanc, Lisa Kudrow and David Schwimmer as a friend group in New York.
As Chandler, Perry played a sarcastic yet insecure and neurotic roommate of Joey and Ross, played by LeBlanc and Schwimmer respectively.
The series was beloved by millions of fans worldwide, with all the main cast members reuniting in 2021 for a reunion special.
The cast of Friends at the 54th Emmy Awards in Los Angeles in 2002.
Perry received one Emmy nomination for his Friends role and two more for appearances as an associate White House counsel on The West Wing.
He also had several notable film roles, starring opposite Salma Hayek in the rom-com Fools Rush In and opposite Bruce Willis in the the crime comedy The Whole Nine Yards.
In recent years, Perry had begun to open up about his health battles with ranged from pancreatitis to alcohol and opioid addiction.
He documented his struggle with addiction and an intense desire to please audiences in his memoir, Friends, Lovers and the Big Terrible Thing.
"Friends was huge. I couldn't jeopardise that. I loved the script. I loved my co-actors. I loved the scripts. I loved everything about the show but I was struggling with my addictions which only added to my sense of shame," he wrote.
"I had a secret and no one could know.
"I felt like I was gonna die if the live audience didn't laugh, and that's not healthy for sure. But I could sometimes say a line and the audience wouldn't laugh and I would sweat and sometimes go into convulsions," Perry wrote.
"If I didn't get the laugh I was supposed to get, I would freak out. I felt that every single night. This pressure left me in a bad place. I also knew of the six people making that show, only one of them was sick."
with AP
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