Uruguayan Bentancur saw his fine 2022-23 campaign cut short in February when he suffered anterior cruciate ligament damage to his left knee during a 4-1 defeat to Leicester.
The ex-Juventus midfielder had been one of Spurs' best performers, scoring six times in 26 appearances last season and after eight months out he is close to a return, but he's not ready for Monday's visit of Fulham.
"No, he won't be in the squad," Postecoglou confirmed on Friday.
"We'll be careful with him. Now he's sort of fully training, so that means he's into the whole session. We've drip-fed him into training the last month and he's coped pretty well with that.
"Now he's into full training. We've got to be mindful that he's missed a fair bit of football, but I think the more he trains with the first team over the next few weeks, we'll sort of pick our moment.
"He's looking good at training and it was great to have him for the last couple of weeks fully integrated with the guys who are here and we're looking forward to having him back."
But leaders Spurs will have vice-captain Cristian Romero and skipper Son Heung-min available for the London derby.
Romero suffered a whack to his ankle in Argentina's 2-0 win over Peru earlier this week, while Son was visibly in discomfort during South Korea's 6-0 victory against Vietnam, although he did play the whole match and score in the friendly.
No issues have been reported since the duo returned to Hotspur Way this week.
Postecoglou added: "It has been a pretty positive international break. In terms of availability I'll start with the internationals first and everybody is back.
"The medical reports seem good so no real issue around the guys from a fitness perspective."
"Playing on a Monday night helps and all the international players should be fine but Brennan (Johnson) we will need to see."
Johnson has not played for Tottenham since the north London derby at Arsenal on September 24 after he sustained a minor hamstring strain.
Spurs, though, will be without Yves Bissouma after he was sent off for two bookable offences at Luton a fortnight ago.
