Bolstered by the return of prolific goalkicker Dakota Davidson, Brisbane have overcome a rare slow start to defeat a gallant Hawthorn by 27 points.
With the Hawks threatening to pull off an upset win with a seven-point lead at halftime, the Lions strung together six unanswered goals to win 8.11 (59) to 5.2 (32) at Kinetic Stadium on Sunday.
Ally Anderson (30 disposals, eight clearances, eight tackles) was brilliant as she fought off former Brisbane teammate Emily Bates (17, five, 14) in the midfield.
Greta Bodey, also a former Brisbane player, kickstarted the game in terrific fashion a minute into the opening term with a left-foot punt from outside the goal square.
Returning from a one-match suspension for rough conduct, Davidson replied instantly for Brisbane after a free kick from push in the back.
Held back by inaccurate kicking, the Lions finished the first term with a three-point lead.
Unable to shake off the yips, the script was flipped on Brisbane in the second quarter with two goals from Hawks speedster Bridie Hipwell and another by Kaitlyn Ashmore.
But clever ball movement by Lions captain Bre Koenen and Cathy Svarc to control the corridor helped Brisbane regain the lead by seven points at third-quarter time.
Unanswered goals across the second half by Isabel Dawes (two goals), Davidson (three), Taylor Smith (one) and Ellie Hampson (one) secured the win for the Lions.
Brisbane (4-1) return home to host 11th-placed Collingwood next round while Hawthorn (1-4) look to put an end to St Kilda's two-game winning streak.