Argentina were unfortunate to lose 22-21 when the teams met in Johannesburg last weekend as they dominated possession and matched the home side physically, but were unable to finish off their numerous entries into the Springboks' 22-metre line.
Cheika has kept largely the same forward pack for Saturday's return fixture, replacing only injured lock Lucas Paulos with Pedro Rubiolo in the No.4 jersey.
The other four changes are all in the backline.Â
Fullback Juan Cruz Mallia has been cited for dangerous play, having clattered into the head of Bok scrum-half Grant Williams after only 11 seconds last week in an attempt to charge down a kick.
The outcome of that hearing has not been released by officials, but Mallia has not been included in the match-day 23.
He has been replaced at fullback by Martin Bogado, with Boffelli coming in on the wing in the place of Mateo Carreras.
Boffelli's return boosts the home side's goal-kicking, with flyhalf Santiago Carreras missing three relatively simple shots at goal last week that proved very costly.
Santiago Cordero replaces Juan Imhoff on the other wing, while the final change sees Gonzalo Bertranou come in at scrumhalf for Lautaro Bazan Velez.
Hooker Augustin Creevy could be the first Argentine player to reach 100 caps if he comes off the replacements' bench.
Argentina team:
Martin Bogado, Emiliano Boffelli, Lucio Cinti, Santiago Chocobares, Santiago Cordero, Santiago Carreras, Gonzalo Bertranou; Juan Martin Gonzalez, Santiago Grondona, Pablo Matera, Tomas Lavanini, Pedro Rubiolo, Francisco Gomez Kodela, Julian Montoya (capt) (capt), Thomas Gallo.
Replacements: Augustin Creevy, Joel Sclavi, Eduardo Bello, Guido Petti, Facundo Isa, Lautaro Bazan Velez, Tomas Albornoz, Matias Moroni.
