To make the top five, the seventh-placed Hurricanes need to win in Launceston and have the Melbourne Stars beat the Sydney Thunder in Wednesday's second fixture.
The Heat, meanwhile, are guaranteed to feature in the finals and can secure third spot on the ladder and a home knockout final with victory over the home side.
A loss means they would meet either the Hurricanes or Thunder in The Eliminator.
The Hurricanes, coming off three losses, have made two changes to the side that lost by 24 runs to the Sydney Thunder on Monday night.
Mac Wright replaces D'Arcy Short, while Wil Parker replaces fellow spinner Paddy Dooley who has a groin injury.
The in-form Heat, who have won their past four matches, are unchanged from a four-run victory over the Stars.
HOBART HURRICANES: Caleb Jewell, Zak Crawley, Mac Wright, Ben McDermott, Tim David, Matthew Wade (capt), Faheem Ashraf, Joel Paris, Nathan Ellis, Wil Parker, Riley Meredith
BRISBANE HEAT: Usman Khawaja (capt), Josh Brown, Marnus Labuschagne, Matt Renshaw, Sam Hain, Jimmy Peirson, James Bazley, Michael Neser, Spencer Johnson, Mitchell Swepson, Matthew Kuhnemann.
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