The deals are thought to be worth in excess of $10 billion ($A15 billion).
The two governments are expected to seal a trade agreement with three pillars: a new science and technology partnership to strengthen the tech sectors of both countries, cooperation in civil nuclear power, and advances in defence technology cooperation, the officials said in a telephone briefing.
Several US tech business leaders are expected to be in attendance for the state visit, the officials said.
Trump and first lady Melania Trump are to arrive late on Tuesday for talks with King Charles and Queen Camilla on Wednesday at Windsor Castle where he will be treated to the usual display of British royal pageantry, including a carriage tour and a lavish state banquet.
The trip will continue on Thursday at Prime Minister Keir Starmer's Chequers country residence where the pair are expected to give a joint news conference.
The president returns to Washington on Thursday night.
Trump is the first US president to be invited to two state dinners by the British. His first was in 2019 during his first term.
The US officials described agreements to come that would be heavy on economic cooperation between the two long-standing allies with at least $US10 billion ($A15 billion) in deals expected.
"This visit gives the president the opportunity to strengthen ties with a particularly close partner and ally, while advancing mutual economic and foreign policy interests," one of the US officials said.
British police said on Monday they had planned for "just about every eventuality" ahead of President Trump's visit, with the bulk of the trip being held out of public view.
Large crowds are expected in Windsor and anti-Trump protesters have said they want to make their views known.
The high-profile trip comes after last week's killing of right-wing activist Charlie Kirk, a staunch ally of Trump, fuelling fears of a spike in political violence in the United States.
"I'm very content that we have planned a very comprehensive policing and security operation that has taken into consideration just about every eventuality of what could happen," Assistant Chief Constable Christian Bunt of Thames Valley Police told reporters.
Bunt said there would be a significant, highly-visible police presence, although he declined to say how many officers were being deployed.
Airspace over Windsor and Chequers would be closed and specialist officers would be ready to deal with any protest that might take place, he added.
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