Strike Force Hawk officers seized numerous stolen motor cars and illegal drugs in the seven-day operation.
The NSW Police strike force was established in October after Toufik Hamze and his son Salim were gunned down and killed on a street.
To date, more than 80 firearms and 3300 rounds of ammunition, $2.9 million in cash, and prohibited drugs worth more than $9 million have been seized.
South West Metropolitan Region Commander Assistant Commissioner Stuart Smith said 52 firearm prohibition order searches took place last week.
"Last week, we targeted the who's who of criminality in Sydney's southwest: Rebels, Finks and Lone Wolves Outlaw Motorcycle Gangs - you'd be hard-pressed to find someone in that world who didn't get a home visit," he said on Monday.
During the operation - which ran between Monday and Friday - police seized around $150,000 in cash, 1.5kg of cannabis, 150 grams of methylamphetamine, numerous prohibited weapons and three stolen cars.
Seven men were arrested after a clandestine drug laboratory was discovered on Friday.
Over the week, 15 men were charged with various offences.
Strike Force Hawke is working with Raptor Squad, Taskforce Erebus - which was recently set up to tackle organised crime following a spate of public place shootings - and the Australian Criminal Intelligence Commission.
"This allows us to target and disrupt organised crime at the street, mid and upper-levels simultaneously within a specific organised crime network or more broadly to prevent violent crime," Assist Comm Smith said.
Meanwhile, the NSW Labor opposition has accused the state government of failing to honour its promise to introduce laws on "unexplained wealth" targeting gang associates and crime bosses.
The laws would allow the NSW Crimes Commission to seize the assets of suspected criminals unable to explain where their "Maseratis, Ferraris, waterside homes and Rolex wristwatches" came from.
Thirteen people have been shot dead in underworld gang-related violence in the past 19 months.