Morocco won a sixth successive game in the qualifiers on Friday (local time) with two goals from Ismael Saibari and one each from Ayoub El Kaabi, Hamza Igamane and Azzedine Ounahi in Rabat.
They are the only side across the nine African qualifying groups with a 100 per cent record.
Tanzania were the sole side still with a chance of catching them in Group E, but their 1-1 draw against Congo in Brazzaville saw them move to 10 points from six games, while Morocco have 18 points.
The Moroccans were the first African country to reach a World Cup semi-final in Qatar in 2022 and have remained the top-ranked African side since.
On a busy night of 14 qualifiers around the continent, Egypt kept their stranglehold on Group A with a 2-0 home win over Ethiopia in Cairo.
Mohamed Salah converted a penalty for his seventh goal of the preliminaries, and Omar Marmoush then took another spot kick for his first of the campaign.
With three games left, Egypt are five points clear of Burkina Faso, who beat bottom-placed Djibouti 6-0 with a double each from Dango Ouattara and defender Edmond Tapsoba.
African champions Ivory Coast went back top of Group F, one point ahead of Gabon who they next play away on Tuesday, when they beat Burundi 1-0 in Abidjan.
A single point also separates leaders Democratic Republic of Congo and Senegal in Group B ahead of a crunch clash between the two in Kinshasa on Tuesday.
Cedric Bakambu scored twice and Yoane Wissa added another as the Congolese won 4-1 in South Sudan, while Senegal were 2-0 home victors over Sudan.
South Africa remain five points clear of second-placed Benin in Group C after both won.
Burnley striker Lyle Foster was among the scorers as South Africa eased past Lesotho 3-0, while Steve Mounie scored the only goal as Benin edged Zimbabwe.
In Group G, Algeria's qualification chances were dramatically enhanced as second-placed Mozambique lost 4-0 in Uganda, while Namibia's defeat by Malawi in Group H means Tunisia will qualify if they beat Equatorial Guinea away on Monday.
The winners of the nine qualifying groups automatically head to the World Cup in North America, with the four best runners-up advancing to a playoff in November, with the potential of a further place at the finals.
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