The Razzies said the film "utterly destroyed HG Wells' classic novel".
"Director Rich Lee (maybe inspired by Ed Wood) chose a goofy gimmick, hack dialogue, and a particularly hilarious performance by its lead, Ice Cube, to seize 2025's biggest number of statues," the parody awards show said on Saturday.
The Razzies, Hollywood's long-running spoof of the Oscars, spotlight the most critically panned performances of each year.
The other major target was Snow White, a 2025 live-action remake of Disney's 1937 animated classic.
The film earned worst supporting actor - for all seven CGI dwarves - and worst screen combo.
"It cost a fortune and lost a fortune, perhaps cursed by Walt himself for having ignored his dying wish for it never to be remade," the Razzies quipped in their announcement.
Australian star Rebel Wilson picked up worst actress for the action comedy Bride Hard, and Scarlet Rose Stallone won worst supporting actress for her role in the Western action film Gunslingers.
The Razzie Redeemer Award - given to a past nominee who has "gone on to better things" - was awarded to Kate Hudson for her widely praised performance as Cartwright-Sardina, one half of a Neil Diamond husband-wife cover band in Song Sung Blue, which she stars in opposite Hugh Jackman.
Hudson's role has earned her strong critical acclaim and best actress nominations from the Golden Globes, Actor Awards and BAFTA Awards. She is also nominated for an Academy Award.
The honour brings Hudson full circle after she previously received several Razzie nods, including worst actress for her role in the 2021 film Music, directed by Australian pop singer Sia.
More than 1100 Razzie voters across the US and roughly two dozen other countries decide the annual winners, according to the organisation's website.
