The 47-year-old actress' global box office haul has rocketed thanks to the release of Avatar: Fire and Ash, taking her from third place on the list to first with a combined total over $15.47 billion thanks to her roles in major franchises including Guardians of the Galaxy and other Marcvel Cinematic Universe films and the Star Trek series.
Zoe was thrilled with the data from the Numbers.
She said in a video shared to Instagram: "I just want to express my sincerest gratitude for the extraordinary journey that has led me to become the highest-grossing film actor of all time today.
"An achievement made possible entirely, entirely by the incredible franchises and the collaborators that I have been fortunate enough to be a part of, to every director who placed their trust in me."
Zoe then praised Star Trek's JJ Abrams, Avengers filmmakers Joe and Anthony Russo, Guardians of the Galaxy director James Gunn and Avatar's James Cameron for "believing my potential for seeing something in me that I have not always seen in myself, and for challenging me to always rise to the occasion".
She added: "Your faith, your guidance and your vision, they shape not only these films, but me as an artist."
The Emilia Perez star - who knocked Scarlett Johansson of the top spot - went on to give a heartfelt thanks to her fans.
She said: "Your unwavering support, passion and loyalty are the true foundation of this milestone.
"None of this exists without you showing up time and time again with open hearts and enthusiasm.
"This accomplishment belongs to all of us, and I'm deeply grateful and profoundly humbled. And may the next record breaker be another woman!"
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