The award-winning Aussie actress admitted being a mother to sons Rocco, nine, and eight-year-old Rafa - whom she has with her 55-year-old husband, actor Bobby Cannavale - is harder than any of her on-screen roles.
Rose, 46, told The Sunday People newspaper's Love Sunday magazine: "It's the hardest thing you'll ever do.
"The role of your life is to be a parent. And I'm married to an actor, so of course it's a constant push and pull of figuring it out and, 'What does my family need? Where is my career going?'"
The Bridesmaids star is not afraid to ask fellow parents how they juggle a hectic work life with raising children.
Rose said: "I think it's hard for any working parent. Honestly, I still ask people, 'How do you do it?'
"Both my sisters work really hard. They're raising kids, they're juggling stuff, and I feel lucky to have help. But it's constantly reassessing - like, 'What do they need? Where am I at?'"
The If I Had Legs I'd Kick You star - who bagged a Best Actress Golden Globe gong in January for her performance as stressed-out mum Linda in the comedy-drama film - revealed Rocco and Rafa have no interest in seeing her on screen.
Rose - who is nominated for an Oscar in the Actress in a Leading Role category for If I Had Legs I'd Kick You - said: "They'd rather watch Stranger Things."
The 28 Weeks Later cast member was rejected from a place in drama school, and Rose went on to study English Literature and Gender Studies at the University of Sydney.
And the snub taught her a valuable lesson, which she now instils in her and Bobby's children.
She said: "You learn resilience, which is what I want to teach my kids.
"I had to be resilient, 'OK, I'm not going to do that. I'm going to keep learning. I'm going to study the things that are interesting to me. I'm going to audition.'"
One of those auditions was for the role of BG, a blind 17-year-old girl, in the 2000 romance-comedy The Goddess of 1967, which is credited with launching Rose's Hollywood career.
She said: 'It was very much a film that shaped and changed me. The film was hard. It was challenging."
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