The updated US intelligence briefing, published on Saturday, says a natural origin and a lab leak are both plausible hypotheses to explain how SARS-CoV-2, the virus responsible for COVID-19, first infected humans, but that the truth may never be known.
In a response Sunday on the website of China's foreign ministry, Wang said "a lie repeated a thousand times is still a lie", adding that US intelligence services "have a reputation for fraud and deception".
"The tracing of the origins of the novel coronavirus is a serious and complex issue that should and can only be researched through the co-operation of global scientists," he said.
China has consistently denied allegations the virus was leaked from a specialist laboratory in the city of Wuhan, where COVID-19 was first identified at the end of 2019.
Wang also repeated China's calls for the United States to open up its own laboratory at Fort Detrick to international experts.
A joint study by China and the World Health Organisation published this year all but ruled out the theory that COVID-19 originated in a laboratory, saying that the most likely hypothesis was that it infected humans naturally, probably via the wildlife trade.
Critics said the study failed to investigate the Wuhan labs and did not examine the raw data required to understand the virus's early transmission routes.
The WHO last month established a new Scientific Advisory Group on Pandemic Origins and called on China to supply the raw data to help any new investigation. China has declined, citing patient privacy rules.
